P20 stability study of a mixed system of sodium benzoate. Sodium benzoate is primarily a preservative and corrosion inhibitor e. Concise international chemical assessment document 26. High levels of ammonia can be reduced quickly when sodium phenylacetate and sodium benzoate injection is. Ingestion of sodium benzoate at the generally regarded as safe gras dose leads to a robust excursion in the plasma hippurate level. The urea cycle is the major pathway of elimination of excess nitrogen including ammonia, and absence of one of the urea cycle enzymes often causes elevations in serum ammonia which can be severe, life. Pdf sodium benzoate sb is a widely used preservative and antimicrobial substance in many foods and soft drinks. Biodegradation of sodium benzoate by pseudomonas biofilm. In this study, the effects of sodium benzoate e211 sb on the liver tissues of. Show this safety data sheet to the doctor in attendance. Sodium phenylacetate and sodium benzoate injection 10% per 10% is a sterile, concentrated, aqueous solution of sodium phenylacetate and sodium benzoate. Benzoic acid and sodium benzoate note that the pagination and layout of this pdf file are not identical to those of the printed cicad first draft prepared by dr a.
An earlier openlabel, pilot, dosefinding trial was performed by dosing sodium benzoate between 250 and mgd. Avoid raising powdered material due to explosion hazard. If the pdf does not display below, you may also download it here. Sodium benzoate has been shown to be an effective inhibitor of the corrosion of mild steel in distilled water, a moderately hard mains.
Sodium phenylacetate and sodium benzoate injection contains 30. Sodium benzoate is the sodium salt of benzoic acid used as a preservative, also in a wide range of cosmetic product types. Sodium benzoate concentrate for injection 125mls 25g as 125 mls of sodium benzoate has been added to the solution there is now 25 grams of sodium benzoate in a volume of 500 mls i. This article provides a detailed overview of sodium benzoate, including its uses and possible safety concerns. Effects of sodium benzoate, a widely used food preservative, on. At these levels, there are no reports of toxic effects in humans. In jaundiced newborns, however, the potential exists for benzoate, if.
Benzoic acid, in the form of sodium benzoate, is a widely used food preservative suitable for acid foods. We report a retrospective multicentre study on the use of i. The concentration of ammonia is 10 times higher in tissue than in blood. It is a widely used food preservative, with an e number of e211.
Sodium benzoate and other metal benzoates as corrosion. Benzoic acid is often used in combination with sorbic. Hyperammonemia is defined as a blood ammonia concentration greater than about 100 mcmoll in neonates or 50 mcmoll in children and adults precise cutoffs vary, depending on individual laboratory normative ranges. Sodium benzoate for the treatment of behavioral and. With the increasing use of the synthesis of hippuric acid as a test of liver function, the toxicity of sodium benzoate requires careful revaluation. Sodium benzoate is deemed safe, and people generally dont exceed the adi of 02. Pdf an overview on the effects of sodium benzoate as a. These compounds have generally recognized as safe gras status. Benzoic acid is an aromatic acid used in a wide variety of cosmetics as a ph adjuster and preservative. However, published data do not provide a clear picture of the benefits and risks of this drug. Methods sixty asa i and ii patients undergoing lower abdominal or lower extremity surgery were included in this study. Sodium benzoate is best known as a food preservative, though it has several other uses. Benzyl alcohol is metabolized to benzoic acid, which reacts with glycine and excreted as hippuric acid in the human body.
The preparation relies on the accurate measurement of each component in a syringe or bag which then mixes via a ysite, immediately prior to administration. Sodium benzoate is a widely used preservative found in many foods and soft drinks. In this study, we developed a method to detect these preservatives in dairy products. Standard hemodialysis was the most frequently used dialysis method. Sodium benzoate sb and potassium sorbate ps have long been used as preservatives in foods and other products. A cinnamon and benzoate free diet for orofacial granulomatosis. Significant changes in anthranilic acid and acetylgycine were observed. Us3078299a preparation of phenyl benzoate and conversion. Sodium benzoate s001 your patch testing results indicate that you have a contact allergy to sodium benzoate. Pdf antimicrobial effects of sodium benzoate,sodium. Us3078299a us102632a us10263261a us3078299a us 3078299 a us3078299 a us 3078299a us 102632 a us102632 a us 102632a us 10263261 a us10263261 a us 10263261a us 3078299 a us3078299 a us 3078299a authority us united states prior art keywords alkali metal potassium benzoate group consisting selected prior art date 196104 legal status the legal status is an. The major preservatives in dairy products are sodium benzoate, potassium sorbate, and natamycin. Cheese and yogurt are two kinds of nutritious dairy products that are used worldwide. Benzoic acid and its sodium and potassium salts are rapidly absorbed after oral administration.
It is the sodium salt of benzoic acid and exists in this form when dissolved in water. Intravenous administration of caffeine sodium benzoate for. Sodium benzoate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. Based on data regarding the amounts of benzoic acid and sodium benzoate produced as a food preservative, fda 1973 estimated a daily per capita intake of 0. It can be produced by reacting sodium hydroxide with benzoic acid. Sodium benzoate is produced by the neutralization of benzoic acid with caustic soda andor soda ash sodium benzoate is found naturally in cranberries, prunes, plums, cinnamon, ripe cloves, and apples.
Sebagai contoh, pada keadaan netral, kurang lebih 4% natrium benzoat diperlukan untuk mencegah pertumbuhan mikroorganisme fermentatif. Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of. Phenylbutyrate and sodium benzoate are orphan drugs approved for the treatment of hyperammonemia in patients with urea cycle disorders, a series of at least 8 rare genetic enzyme deficiencies. Biofilm and planktonic bacterial growth dynamics were monitored by plate counts, and optical density measurements 230nm determined benzoate biodegradation. Effect of sodium benzoate preservative on micronucleus induction. Description download pemerian natrium benzoat comments. It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. Sodium benzoate 532321 99 100% all concentrations are percent by weight unless ingredient is a gas. This contact allergy may cause your skin to react when it is exposed to this substance although it may take several days for the symptoms to appear. Swelling and redness are the most common symptoms but other symptoms such as mouth ulcers and cracked lips can occur too. Sodium benzoate structure source pubchem what is sodium benzoate. A cinnamon and benzoate free diet orofacial granulomatosis ofg is a condition which affects mainly the mouth and lips.
Your patch test result indicates that you have a contact allergy to sodium benzoate. Safety data sheet according to 29cfr19101200 and ghs rev. Melber, fraunhofer institute for toxicology and aerosol research, hanover, germany. Fisher scientific 1 reagent lane fair lawn, nj 07410 for information, call. Note that the paginationand layout of this pdf file are not. Sodium benzoate, a damino acid oxidase daao inhibitor, improved cognitive function of earlyphase alzheimers disease ad after 24week treatment. The maximum permitted levels for these additives in cheese and yogurt are established according to iranian national standards. Final report on the safety assessment of benzyl alcohol.
Currently, concentrated solutions of each component are available. Sodium benzoate is a food preservative approved by the world health organization and is also approved for treatment of urea cycle enzymopathies. This study examined benzoate treatment for behavioral and psychological symptoms of dementia bpsd. A comparative study of the effects of the two preservatives, sodium. Report pemerian natrium benzoat please fill this form, we will try to respond as soon as possible. A worldwide yearly survey of new data in adverse drug reactions. It has a role as an antimicrobial food preservative, a drug allergen, an ec 1. Pdf effects of sodium benzoate, a commonly used food. Benzoic acid was discovered in the 16th century by dry distillation of gum benzoin, first described by nostradamus. Background and objectives in this study, we evaluated the efficacy and safety of prophylactic administration of intravenous caffeine sodium benzoate for postdural puncture headaches pdph on patients administered spinal anesthesia. It is metabolized within mitochondria to produce hippurate, which is then cleared by. Benzoic acid and sodium benzoate european commission.
Sodium benzoate is a substance which has the chemical formula c 6 h 5 coona. Sodium benzoate biodegradation capacities of these species were compared under batch and continuous operations. Thus, sodium phenylacetate and sodium benzoate injection should be used with great care, if at all, in patients with congestive heart failure or severe renal insufficiency, and in clinical states in which there is sodium retention with edema. Accidental release measures personal precautions, protective equipment and emergency procedures. The cause is not known but a cinnamon and benzoate free diet helps 70% of people with ofg. Scientific opinion on the reevaluation of benzoic acid e. Acute sodium benzoate did not significantly impact glucose, insulin, or glucagon. Benzoate is effective in increasing the excretion of urinary nitrogen in patients with hyperammonemia. Capitals indicate lifethreatening, underlines indicate most frequent.
98 1240 1469 486 58 959 907 1019 90 452 514 583 246 565 903 202 1166 1238 120 1524 1342 346 1491 1257 605 1161 1094 750 1336 1364 527 366 1112 550 275 19 1437 1315 153 238 93 1328 11 1174 762